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Search Results to Alan Tackett

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One or more keywords matched the following properties of Tackett, Alan

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overview My laboratory focuses on histone epigenetic mechanisms that regulate gene transcription and that are coupled to melanoma progression. We utilize a suite of techniques in our studies including proteomics of human biopsies, immunohistochemistry, cell culture, tumorigenicity assays, ChIPseq, biochemical and proteomic approaches for analyses of protein complexes, and cutting-edge mass spectrometry for the analysis of histone post-translational modifications. We have a unique environment that provides for discovery-based studies like proteomics as well as hypothesis-driven studies like those we perform in cell culture and with skin biopsies. In addition to our melanoma work, we develop new technologies for epigenetic studies such as tools for detection of in vivo protein interactions and quantitative assays for histone modifying proteins.

One or more keywords matched the following items that are connected to Tackett, Alan

Item TypeName
Academic Article MassSQUIRM: An assay for quantitative measurement of lysine demethylase activity.
Academic Article Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen.
Academic Article Identification of PTHrP(12-48) as a plasma biomarker associated with breast cancer bone metastasis.
Academic Article A quantitative proteomic analysis of FFPE melanoma.
Concept Breast Neoplasms
Concept Bone Neoplasms
Concept Brain Neoplasms
Concept Colonic Neoplasms
Concept Lung Neoplasms
Concept Epigenomics
Concept Skin Neoplasms
Concept Thyroid Neoplasms
Concept Pancreatic Neoplasms
Concept Neoplasms, Experimental
Concept Neoplasms
Academic Article Quantitative Proteomics Identifies Activation of Hallmark Pathways of Cancer in Patient Melanoma
Academic Article TBX2 blocks myogenesis and promotes proliferation in rhabdomyosarcoma cells.
Academic Article A CRISPR-based approach for proteomic analysis of a single genomic locus.
Academic Article Disruption of BRD4 at H3K27Ac-enriched enhancer region correlates with decreased c-Myc expression in Merkel cell carcinoma.
Academic Article Proteomic Identification of DNA-PK Involvement within the RET Signaling Pathway.
Academic Article Bioorthogonal labeling cell-surface proteins expressed in pancreatic cancer cells to identify potential diagnostic/therapeutic biomarkers.
Academic Article ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor Growth.
Academic Article Role of EZH2 histone methyltrasferase in melanoma progression and metastasis.
Academic Article Quantitative Proteomics Identifies Activation of Hallmark Pathways of Cancer in Patient Melanoma.
Academic Article KDM5 lysine demethylases are involved in maintenance of 3'UTR length.
Academic Article CD109 Overexpression in Pancreatic Cancer Identified by Cell-Surface Glycoprotein Capture.
Academic Article Immune surveillance in melanoma: From immune attack to melanoma escape and even counterattack.
Academic Article Do checkpoint inhibitors rely on gut microbiota to fight cancer?
Academic Article Chromatin-mediated regulators of meiotic recombination revealed by proteomics of a recombination hotspot.
Academic Article An N6-methyladenosine at the transited codon 273 of p53 pre-mRNA promotes the expression of R273H mutant protein and drug resistance of cancer cells.
Academic Article Loss of E-Cadherin Inhibits CD103 Antitumor Activity and Reduces Checkpoint Blockade Responsiveness in Melanoma.
Grant Using ChAP-MS to Study Macromolecular Chromatin Composition during Transcription
Grant Development of MassSQUIRM to Quantitatively Measure Lysine Methylation
Grant Center for Studies of Host Response to Cancer Therapy
Grant Development of technology for high resolution epigenetic profiling of chromatin
Grant Technology for Identification of Epiproteomes in Tissue Samples
Grant Identifying the Epigenetic Regulation of Arsenic Exposure
Grant Functions and Mechanisms of Helicases and G-Quadruplex Nucleic Acids
Academic Article Proteomic characterization of the arsenic response locus in S. cerevisiae.
Grant Epigenetic profiling and enzymatic regulation of H3K23me3 during cellular differentiation - Continuation - Continuation - Continuation
Grant Epigenetic regulation of metabolic stress pathways in melanoma infiltrating lymphocytes- Resubmission
Academic Article Current state of melanoma diagnosis and treatment.
Academic Article Histone Modifications as Biomarkers for Immunotherapy.
Academic Article Utility of histone H3K27me3 and H4K20me as diagnostic indicators of melanoma.
Academic Article Proteogenomic analysis of melanoma brain metastases from distinct anatomical sites identifies pathways of metastatic progression.
Academic Article Epigenetic Control of Cdkn2a.Arf Protects Tumor-Infiltrating Lymphocytes from Metabolic Exhaustion.
Academic Article Durable Suppression of Acquired MEK Inhibitor Resistance in Cancer by Sequestering MEK from ERK and Promoting Antitumor T-cell Immunity.
Academic Article Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer.
Academic Article Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells.
Academic Article Phase separation drives aberrant chromatin looping and cancer development.
Academic Article Anti-PD-1/L1 lead-in before MAPK inhibitor combination maximizes antitumor immunity and efficacy.
Academic Article A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells.
Academic Article Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy.
Academic Article Genomic and Transcriptomic Profiling of Brain Metastases.
Academic Article Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic.
Academic Article Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer.
Academic Article Expression of integrin ?-7 is epigenetically enhanced in multiple myeloma subgroups with high-risk cytogenetics.
Academic Article Oncogenic signaling-mediated regulation of chromatin during tumorigenesis.
Academic Article Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction in a Colorectal Cancer Model.
Grant Proteogenomic analysis of responders versus nonresponders in a Phase I clinical trial of Th17-inducing dendritic cell vaccination for advanced stage ovarian cancer
Grant Center for Molecular Interactions in Cancer (CMIC)

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  • Cancer
  • Epigenetics